Dr. Ehsan Karimiani
• Qualifications: MD, MRes, PhD (University of Manchester, Medical Genetics)
• Experience: Over 8 years of NHS experience and academia
• Languages: English, French, Persian
• Specialties:

• Genetic counselling for familial cancers (e.g., breast cancer, Lynch
  syndrome, FAP)
• Prenatal and preimplantation genetic testing
• Genetic risk assessments and counselling
• Genetic testing for developmental delays and intellectual disabilities
• Genetic counselling for individuals from Middle Eastern and
  diverse ethnic backgrounds

Commitment: Providing personalised care and support to patients seeking
genetic counselling

Dr. Ehsan Karimiani MD MRes PhD is a renowned medical geneticist with a strong academic foundation and extensive clinical experience. He obtained his Medical Doctorate (MD) degree and completed his Master of Research (MRes) and Doctor of Philosophy (PhD) in medical genetics at the prestigious University of Manchester. Following his academic pursuits, he gained valuable clinical experience through seven years of practice in NHS hospitals.

Ehsan is dedicated to advancing patient care in Iran, where he leverages his expertise to diagnose and treat genetic conditions. He is also an honorary lecturer in medical genetics at University College London, contributing to the field through research and education. With over eight years of experience in genetic counselling, he provides comprehensive guidance to individuals and families affected by genetic disorders. His specialisations include counselling for related marriages, risk assessment for genetic disorders, and premarital and pre-pregnancy genetic counselling. Additionally, he offers specialised counselling for familial cancer syndromes, including breast cancer, Lynch syndrome, and familial adenomatous polyposis (FAP).

Ehsan also provides cancer risk assessments, pre- and post-genetic test counselling, counselling for preimplantation genetic testing (PGT), and prenatal diagnosis (PND). He ensures that patients receive comprehensive explanations of genetic tests and their implications.

His extensive knowledge about the genetic challenges faced by individuals from Middle Eastern ethnicities allows him to provide tailored care and support to patients from this population. Ehsan’s expertise in genetic medicine makes him a valuable resource for individuals and families seeking genetic counselling and support. He is committed to providing personalised care and guidance to help patients understand their genetic risks and make informed decisions about their health.

• Hereditary Cancer Prevention  
  – Predisposition Cancer Scoring (12 cancer types): Evaluates genetic markers associated with increased risk for 12 common cancers, including:
  1. Breast cancer
  2. Lung cancer (including bronchus)
  3. Prostate cancer
  4. Colorectal cancer (colon and rectal)
  5. Melanoma (skin cancer)
  6. Bladder cancer
  7. Non-Hodgkin’s lymphoma
  8. Kidney cancer (renal cell and renal pelvis)
  9. Endometrial cancer (uterine)
  10. Leukemia
  11. Pancreatic cancer
  12. Thyroid cancerThis test helps identify individuals who may benefit from enhanced screening or preventive measures, allowing for early detection and intervention.
  £350

1. 1. – Comprehensive Exome-based Hereditary Cancer Screening: Analyses the entire coding region of DNA to detect mutations in genes linked to hereditary cancer syndromes. This thorough assessment provides a comprehensive view of genetic cancer risk, enabling personalised prevention strategies.
      £690.
   2. Hereditary Disease Prevention 
      – Predisposition Risk Scoring (15+ conditions): Assesses genetic risk factors for multiple common hereditary diseases, such as heart disease, diabetes, and certain cancers. This test allows for early intervention and lifestyle modifications, potentially preventing or delaying disease onset.
      £310
   3. Hereditary Disease Diagnostics  
      – Diagnostic Exome: Examines all protein-coding genes in the genome to identify genetic variants causing rare inherited disorders. This test is particularly useful for diagnosing complex or undiagnosed genetic conditions, offering insights into rare diseases.
      £690
   4. – Autism CGH Array: Uses comparative genomic hybridisation to detect chromosomal abnormalities, including deletions and duplications, associated with autism spectrum disorders. This test helps identify specific genetic causes of autism, aiding in diagnosis and treatment planning.
      £970
   5. – Autism – Exome-based: Provides a comprehensive analysis of all protein-coding genes to identify mutations associated with autism spectrum disorders. This test offers a deeper understanding of the genetic factors contributing to autism, potentially leading to more targeted interventions.
      £1,1104.
   6. Carrier Screening  
      – Comprehensive Carrier Screening (400+ conditions including Cystic Fibrosis, GJB2, etc.): Tests for genetic mutations that could be passed on to children, including those causing cystic fibrosis, GJB2-related hearing loss, and Tay-Sachs disease. This screening is essential for family planning, allowing couples to make informed decisions about reproduction.
      £690
   7. Pharmacogenetics Test: Analyses genetic variations that influence how an individual metabolises and responds to different medications. This test helps healthcare providers optimise drug selection and dosing, reducing adverse effects and improving treatment efficacy. It is particularly useful for tailoring treatments in various medical fields.
      £490
   8. These tests collectively offer a comprehensive approach to genetic health assessment, from cancer prevention to personalised medication management, providing valuable insights for individuals and healthcare providers alike.

Dr Ehsan Ghayoor Karimiani, MD, MRes, PhD

Consultant in Genomic Medicine